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To the best of our knowledge, this is the lone study deciphering differential regulations of V. Some of these identified, differentially regulated proteins are also conferring abiotic stress responses illustrating harmony amongst different stress responses. mungo involves redirection of carbohydrate flux towards pentose phosphate pathway. The robustness in induction of defense/stress and signal transduction related proteins is the key factor in inducing resistance. Conclusionsīiochemical and proteomic analyses revealed early accumulation of the defense/stress related proteins involved in ROS metabolism during incompatible interaction. These nodal proteins play the crucial role of key regulators in bringing about a coordinated defense response in highly orchestrated manner. The network of various cellular pathways that are involved in inducing defense response contains several conglomerated cores of nodal proteins, of which ascorbate peroxidase, rubisco activase and serine/glycine hydroxymethyl transferase are the three major hubs with high connectivity. Quantitative real time PCR analyses of selected genes corroborates with respective protein abundance during incompatible interaction. It was revealed that Photosystem II electron transports are the primary targets of MYMIV during pathogenesis. Differential intensities of chlorophyll fluorescence and chlorophyll contents are in congruence with proteomics data. Among these, photosynthesis related proteins were mostly affected in the susceptible genotype resulting in reduced photosynthesis rate under MYMIV-stress. Proteins of several functional categories were differentially changed in abundance during both compatible and incompatible interactions. Comparative proteome analyses using two-dimensional gel electrophoresis coupled with mass spectrometry identified 109 differentially abundant proteins at 3, 7 and 14 days post MYMIV-inoculation. In the resistant genotype the activities of superoxide dismutase and ascorbate peroxidase increased significantly, while catalase activity decreased. Resultsīiochemical analysis revealed an increase in phenolics, hydrogen peroxide and carbohydrate contents in both compatible and incompatible interactions but the magnitudes were higher during incompatible interaction. mungo genotypes were executed to get an insight in the molecular events during compatible and incompatible plant-virus interactions. In this study biochemical analyses in conjunction with proteomics of MYMIV-susceptible and -resistant V. mungo and MYMIV pathosystem are yet to be explored. The molecular events occurring during compatible and incompatible interactions between V. Taken together, our results support an intricate control of cell survival/death modulated by oxidative stress, apoptosis and autophagy in synthetic cathinones-induced renal injury.Vigna mungo, a tropical leguminous plant, highly susceptible to yellow mosaic disease caused by Mungbean Yellow Mosaic India Virus (MYMIV) resulting in high yield penalty. Importantly, these antioxidant agents significantly aggravated renal cell death induced by cathinone derivatives, most likely due to their autophagy-blocking properties. Both drugs triggered a rise in reactive oxygen and nitrogen species formation, which was completely prevented by antioxidant treatment with N‑acetyl‑L‑cysteine or ascorbic acid. Moreover, the autophagy inhibitor 3-methyladenine significantly potentiated cell death, indicating that autophagy may serve as a cell survival mechanism that protects renal cells against synthetic cathinones toxicity. Both drugs elicited apoptotic cell death and prompted the formation of acidic vesicular organelles and autophagosomes in HK-2 cells. 3,4-DMMC and methylone were selected to further elucidate the mechanisms behind synthetic cathinones-induced cell death. All four derivatives elicited cell death in a concentration- and time-dependent manner, in the following order of potency: 3,4-DMMC > MDPV > methylone ≈ pentedrone. In this study, the potential in vitro nephrotoxic effects of four commonly abused cathinone derivatives, namely pentedrone, 3,4-dimethylmethcatinone (3,4-DMMC), methylone and 3,4-methylenedioxypyrovalerone (MDPV), were assessed in the human kidney HK-2 cell line. Kidney injury has been reported in intoxications associated with synthetic cathinones, but the molecular mechanisms involved have not been explored yet. Synthetic cathinones abuse remains a serious public health problem.